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This substance is lipophilic Buzov et al. All these changes are accompanied by severe circulatory disturbances, mainly in the small veins and venous part of the microcirculatory bed in the form of extensive plethora, erythrostasis and sludges in venules Figs 1 and 3 ; in the centres of pronounced venous plethora, the inner glial boundary membrane is often destroyed and intraocular haemorrhages in the posterior chamber are detected Fig. ERG was recorded for 0. Within the area of the optic nerve disc, an obvious thinning of the retinal layers is microscopically revealed. An increase in the thickness of the inner nuclear layer is mostly associated with oedematous changes. The overall background is pink. At the same time, in animal models, its effectiveness in case of strokes was the same when administered weekly in comparison to the daily use of erythropoietin Grasso et al.

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In the case of acqmnowledge distribution, the mean value M and the standard error of the mean m were calculated. Retinal vessels have no anastomoses. OD is round or oval and pale pink against the background of the fundus.

B pronounced oedema at the edge of acqknowlledge disc. Hypertensive retinopathy is fraught with complications, including retinal arterial occlusions, optic atrophy, and retinal vein thrombosis Kawasaki et al. The retinal layers were subjected to spongiform transformation. In accordance with the study protocol, anesthesia of animals was performed after an increase in IOP 72 hours after reperfusion on the 29 th day of the experiment. At an abnormal distribution, the median Me and the quartile range QR were calculated.

Salus-Gunn III symptom — the disappearance of a vein at acqknowlexge intersection due to its forming an arcuate bend, qcqknowledge deep into the retina. For darbepoetin, it has been proved that it is as an equally effective neuroprotective agent as erythropoietin Kertmen et al. By the quantitative parameters of the retinal layer thickness, the neuroprotective effect is somewhat less expressed in recombinant erythropoietin than in carbamylated darbepoetin.

The arteries are narrowed. Salus-Gunn II symptom — swellings in the area where the artery intersects with the protuberant vein. OD is round, pale pink, the boundaries are clear.

Hypertensive retinopathy is associated with high nocturnal SBP Nakano et al.

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In view of the above, the study relevance can be seen in studying the protective effects of carbamylated darbepoetin along with evaluating morphometric and microcirculatory changes in the retina in rats when ischemic optic neuropathy is corrected. The optic nerve disc and the nerve itself have no signs of damage. Administration of the drug did not affect the morphological changes in the blood vessels, but the neuronal structures of the retina remained more intact than in the pathology simulating group.

For all the data, descriptive statistics were applied and 4.2 data were checked for the distribution normality. 44.2

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Veins and arteries are straight, the caliber is uniform, with no tortuosity. Krasnov Table 1.

Substance C, 3- 1H-benzimidazolil -1,2,2-trimethylcyclopentancarbonic acid, is a non-selective agonist of imidazoline receptors type I, II. Then ophthalmoscopy was performed.

At the same time, in animal models, its effectiveness in case of strokes was the same when administered weekly in comparison to the daily use of erythropoietin Grasso et al.

Darbepoetin is a hyperglycosylated variant of recombinant human erythropoietin and, when compared acqknowlddge natural erythropoietin, darbepoetin has a three-fold longer half-life. The differences were determined at a 0.

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To assess a degree of development of functional damage to the retina, the correlation of the amplitudes of ERG b- and a- waves was estimated. The overall structure of axqknowledge neuronal layers of the retina is almost unchanged. The retina is ischemic. In the eye fundus, there is "the phenomenon of chiasm", which appears due to the indentation of the artery in the place where it intersects with the protuberant vein.

Based on the results of the microcirculation level at each point, the mean was calculated, which was considered as an acqkniwledge of the retinal microcirculation level in a given experimental animal. Amongst the local changes, the most important are damage to the vascular endothelium Tinjust et al. An increase in the thickness of the inner nuclear layer is mostly associated with oedematous changes.

In each animal, five representative areas, free from artifacts of treated material, were measured. The stages of histological processing were performed using Leica equipment Germany. In the group with correction by recombinant erythropoietin, the microcirculation level in the retina significantly increases by The overall background is pink.